Zoe Lyons Opens Up About Relationship Breakdowns, HRT Scares & Her Midlife Crisis

Is It Hot In Here? Midlife Podcast

April 13, 2026 ∙ 51 mins
Episode 23

About

Menopause or midlife crisis?


In this week’s episode, Dr Naomi Potter is joined by comedian Zoe Lyons for a funny, raw and surprisingly moving conversation about what menopause can really do to your mind, confidence, work and relationships. Zoe opens up about the hot flushes that hit out of nowhere, the depression and rage that followed, and why she bought a sports car.


Together, Naomi and Zoe talk about HRT, testosterone, brain fog, motivation, exercise, therapy and the strange grief of feeling like you’ve lost the version of yourself you used to know. If you’ve been feeling flat, overwhelmed, unlike yourself or tempted to run away from your life, this episode will make you feel very seen.


💬 Topics include:

• Menopause symptoms

• Why menopause can feel like a midlife crisis

• Menopause at work

• Relationship strain during midlife

• HRT for menopause symptoms

• Menopause rage

• Brain fog

• Testosterone in women

• Exercise and running for menopause

• Body image and ageing


Follow Is It Hot In Here? podcast on Instagram at @podcast_naomipotter


Follow Zoe Lyons below:

Zoe’s Instagram: @zoelyonscomedy


Listen to Zoe's running & comedy podcast The Running Joke: https://open.spotify.com/show/2Hd4lR0ynIlEcSvMRNGrPv?si=fe38e79a62744a5f


Follow Dr Naomi Potter below:

Naomi’s Instagram: @dr_naomipotter

Naomi’s TikTok: @dr_naomipotter


More info and menopause support at: https://www.menopausecare.co.uk/


0:00 – Zoe Lyons on perimenopause and comedy

1:29 – Zoe’s first symptoms and starting HRT

2:31 – Covid, midlife crisis and everything falling apart

5:56 – How therapy helped save Zoe’s relationship

9:48 – Why menopause changed her confidence and work

13:42 – Depression, low mood and menopause

15:07 – How running helped her mental health

19:06 – Zoe’s HRT journey: tablets, gel and progesterone

24:20 – Brain fog, low motivation and low testosterone

32:00 – Why menopause information still feels confusing

33:49 – Can you stay on HRT forever?

38:05 – Menopause hair loss, skin changes and aging

43:10 – Is it a midlife crisis or perimenopause?

45:20 – How to reconnect with your ageing body


#menopause #midlifecrisis #zoelyons

Information

Podcast

Is It Hot In Here? Midlife Podcast

Episode

23

Date

April 13, 2026

Length

51 mins
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Is It Hot In Here? Midlife Podcast

Part open-clinic, part talk show, this is the podcast for women navigating perimenopause, menopause, and midlife health. Each week, menopause Doctor Naomi Potter is joined by a new guest to explore the real-life impact of their hormonal changes. From hot flushes and anxiety, to brain fog and sleep problems, no topic is off limits. Whether […]

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