About
The Menopause Mastery Show | Your Gut Is Talking to Your Hormones: The Menopause Microbiome Connection | Ep. 295 with Dr. Eddie Romo
🌿Welcome to The Menopause Mastery Show!
👉 What if your gut microbiome is influencing far more than digestion? In this episode of Menopause Mastery, Dr. Betty Murray sits down with microbiologist Dr. Eddie Romo, to explore the powerful connection between the gut microbiome, estrogen metabolism, menopause, inflammation, and brain health.
Dr. Romo explains why the microbiome should be viewed as an active metabolic ecosystem—not simply a collection of "good" and "bad" bacteria. They discuss the estrobolome, the role gut bacteria play in estrogen recycling, and why changes in estrogen during perimenopause and menopause can also change the microbiome.
The conversation also challenges the idea that probiotics are a universal solution. Dr. Romo explains why personalized, longitudinal microbiome testing may provide a much clearer picture than a single snapshot, and why factors like diet, sleep, exercise, stress, hormones, fiber, fermented foods, and polyphenols all matter.
They also explore the emerging relationship between the gut and Alzheimer's risk, systemic inflammation, the blood-brain barrier, hormone replacement therapy, and women's health—and discuss the future of more personalized microbiome and hormone testing.
☑️ Your gut microbiome is an active part of your biology—not a passive collection of bacteria. Supporting a healthy, diverse gut ecosystem may be an important piece of protecting hormonal balance, metabolic health, and brain function throughout menopause and beyond!
🔗 To connect with Dr. Romo:
https://www.instagram.com/dr.eddieromo
https://www.phbio.ai/
00:00:00 — Introduction: Menopause, Hormones & the Microbiome
00:01:27 — Dr. Eddie Romo's Journey Into Microbiology
00:03:27 — Your Microbiome Is More Than "Bacteria"
00:04:38 — The Gut-Brain Connection & Alzheimer's
00:06:40 — Alzheimer's Isn't Just a Disease of the Brain
00:08:07 — Why Brain Plaques May Not Tell the Whole Story
00:09:18 — Leaky Gut, Inflammation & Brain Health
00:10:28 — The Microbiome-Hormone Connection
00:12:14 — What Is the Estrobolome?
00:14:17 — Beta-Glucuronidase & Estrogen Recycling
00:15:27 — Why the Microbiome Changes During Menopause
00:18:03 — AI & The Future of Personalized Health
00:19:21 — Why Women's Health Research Matters
00:20:03 — Estrogen, Gut Lining & Microbial Diversity
00:22:18 — Inflammation Is Multifactorial
00:24:19 — Hormone Replacement Therapy & the Gut
00:26:42 — Could Hormone Therapy Affect Your Microbiome?
00:27:23 — Menopause, IBS & Digestive Symptoms
00:28:45 — Are Probiotics Overhyped?
00:30:42 — Why Your Microbiome Is Uniquely Yours
00:31:30 — Why Longitudinal Microbiome Testing Matters
00:32:18 — From Probiotics to Personalized Interventions
00:33:34 — Fiber, Fermented Foods & Polyphenols
00:35:01 — The Future of Microbiome Testing
00:36:39 — Your Microbiome Is Constantly Changing
00:37:29 — Toward Personalized Microbiome Recommendations
00:38:22 — Why Current Microbiome Testing Has Limitations
00:40:30 — Condition-Specific Microbiome Testing
00:42:05 — The Bigger Picture: Hormones + Gut + Systemic Health
00:43:18 — Where to Follow Dr. Romo & What's Coming Next
00:44:30 — What's Next for Menopause Mastery
00:45:10 — Closing & Listener Call to Action
📌 Connect with Dr. Betty Murray:
Website: https://www.drbettymurray.com/
Instagram: https://www.instagram.com/drbettymurray/
✅ Let us know what you think! Like, comment, and subscribe on YouTube:
@drbettymurray
🔗 Links:
🔹The Fierce Female Method for Longevity (Dr. Betty's book):
https://fierce.hormoneshelp.com/
🔹Menrva Telemedicine: https://gethormonesnow.com/
🔹Living Well Dallas: https://www.livingwelldallas.com/
🎙️ More from the Podcast: Subscribe to #MenopauseMastery → https://www.youtube.com/channel/UCwONPdSvb2-YYY74VhD-XBw Apple Podcasts → https://podcasts.apple.com/us/podcast/menopause-mastery/id1607369247 Spotify → https://open.spotify.com/show/0tNsjm32CZNXSgSFEwS3uH
Thank you for listening to Menopause Mastery. Empowering your health journey, one episode at a time.
#menopausemastery #menopausepodcast #drbettymurray #menopause #perimenopause #postmenopause #andropause #womenshealth #hormonehealth #guthealth #microbiome #midlifehealth