image of woman with dark hair named Mary Claire Haver

The Ovary’s Job Doesn’t End at Menopause: A Top Neuroscientist Explains

unPAUSED with Dr. Mary Claire Haver

July 21, 2026 ∙ 71 mins
Episode 53

About

In this episode of unPAUSED, Dr. Mary Claire Haver talks with Dr. Jennifer Garrison, a neuroscientist and entrepreneur, about why the ovary should never have been labeled a purely reproductive organ. Dr. Garrison explains that ovaries function like a second brain in the body, sending and receiving chemical signals to nearly every tissue system including the heart, bones, brain, immune system, and metabolism. She walks through her research on the hypothalamus and the brain ovary signaling network, describing how inflammation in this part of the brain may be one of the earliest drivers of aging across the whole body.

The conversation covers why the ovary ages roughly two and a half times faster than the rest of the body, a gap that helps explain the health span difference between women and men. Dr. Garrison and Dr. Haver discuss how poor ovarian function shows up across a woman's life, not only at menopause, contributing to conditions like polycystic ovarian syndrome, infertility, early menopause, depression, metabolic disease, and autoimmune disease. They also unpack why autoimmune conditions rise sharply after menopause and why women's immune systems respond differently to viruses than men's.

Guest links:

Jennifer Garrison, PhD (LinkedIn)

Jennifer Garrison (X)

Jennifer Garrison (Bluesky)

Jennifer Garrison (X Prize)
Jennifer Garrison (The Institute)

Books

“The New Perimenopause,” by Dr. Mary Claire Haver

“The New Menopause"⁠ by Dr. Mary Claire Haver

For full show notes, please click here.

Information

Podcast

unPAUSED with Dr. Mary Claire Haver

Episode

53

Date

July 21, 2026

Length

71 mins
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    In this episode of Not Your Mother’s Menopause Podcast, Dr. Fiona Lovely sits down with Dr. Louann Brizendine, the renowned neuropsychiatrist and author of the groundbreaking book The Upgrade (released in 2022). Dr. Brizendine, who founded the first U.S. clinic focused on women’s mood and hormone-related brain function, brings her decades of expertise to a […]

  • Ep 537: Dr. Deb Butler on Are You Awesome Today?Podcast

    If you’ve spent years believing that successful weight loss in menopause comes from finding the perfect diet, this conversation may change the way you think about food forever. In this guest appearance on the Are You Awesome Today? podcast with Stephen Schener, I share why I believe lasting weight loss begins with understanding your brain […]

  • 85 – Why being healthy feels so hard, and how to change it

    We’re surrounded by advice about what to eat, how toexercise and the latest wellness trends. Yet despite having more health information than ever before, many people feel overwhelmed, exhausted and nohealthier. This week, Dr Louise Newson is joined by nutritionist, podcast host and bestselling author Sarah Ann Macklin to explore why looking after our health […]

  • Why “Eating Healthy” and Doing More Cardio Isn’t Moving the Scale After 50

    Why “Eating Healthy” and Doing More Cardio Isn’t Moving the Scale After 50 You're doing the cardio. You're eating healthy. You're trying so hard… so why isn't the scale moving? If you're over 50 and feel like you're doing everything "right" but still can't lose weight, this episode is for you. I'm breaking down the […]

  • 225: GLP-1 the Magic Miracle Medicine (update) Should EVERYONE take IT?

    GLP-1 was completely under estimated by the medical community and has turned out to be ALMOST a MIRACLE therapy for ALMOST everything.We review how we got this SO wrong and missed the potential of this therapy and ALL of the NEW and POTENTIAAL benefits.We also review the down side and potential Adverse Effects – Mild […]

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    5 Relationship Red Flags Even Smart Women Ignore

    Toxic relationship red flags are easy to miss when you’re the one living inside them. You can fix your sleep, dial in your protein, do every single thing right as you build your next chapter, and if you’re coming home to a partner who quietly drains you, none of it works. Your body keeps the […]

  • The Manipulation Expert: How to Spot Hidden Manipulators & Take Your Power Back

    In today’s episode, you’ll learn the hidden signs of a manipulative, toxic person from the #1 researcher in the world on dark personalities, Dr. Leanne ten Brinke, PhD.  She is here to teach you how to spot the poisonous people that are hidden in plain sight around you – in your family, your community, and […]

  • "Little Joe would’ve watched Heartstopper in secret!" Joe Locke: queer representation matters

    Joe Locke was doing his A levels on the Isle of Man when Heartstopper came out on Netflix. Two days later he had 3 million new Instagram followers. In this chat, Fearne and Joe both share their experiences of being thrust into the spotlight as teenagers, and how it’s affected them mentally. He explores his […]

  • 6 ways to shift midlife belly fat (without counting calories)

    6 ways to shift midlife belly fat (without counting calories) Wondering why your waistline has changed in your 40s or 50s, despite eating well and exercising regularly? Liz explains how perimenopause hormone shifts can change where we store fat, and why muscle loss, poor sleep, stress and gut health all play a role. She also […]

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    Lift Heavy, Protect Your Brain: Strength, Creatine, and Sauna for Women with Dr. Stacy Sims

    In this episode of unPAUSED, Dr. Mary Claire Haver continues her conversation with exercise physiologist and nutrition scientist Dr. Stacy Sims, moving from what does not work to what actually does for women in perimenopause and menopause. They cover why strength training, not endless cardio, is one of the most powerful tools women have for […]

  • Easy ways to build strength and protect mobility after 50 – with Will Harlow

    Tight muscles, weak muscles and stiff joints are the leading causes of pain in later life – and physiotherapist Will Harlow says there’s plenty we can do to protect our comfort, mobility and independence as we age.   He breaks down the simple tests we can do at home to check our strength and balance, […]

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    What No One Tells You About Grief After Losing Your Mother

    This one is for all the women out there who lost their mothers. If you’ve ever wondered why grief from a mother’s death doesn’t follow the timeline the world expects, why it surges at 51 when you pass the age your mother died, why menopause brings a wave of loss that has nothing to do […]

  • Menopause is Inevitable. Suffering through it isn’t with Dr. Somi Javaid

    S.2. Ep4 This episode is for every woman who has ever felt like something is shifting… and no one is really talking about it in a way that makes sense. The identity changes. The body changes. The emotions that feel louder, sharper, or harder to ignore. The quiet realization that the life you’ve built might […]

  • 86 – Why so many women stop feeling like themselves Elinor Wilde

    Many women suddenly start feeling anxious, overwhelmed or unlike themselves during times of hormonal change. They often assume they’re no longer coping or are told it’s simply stress, depression or the pressures of everyday life, while the role of changing hormones is never considered. In this episode, Dr Louise Newson is joined by therapist and […]

  • How to Increase Your Emotional Intelligence & Never Get Angry or Bothered by Anyone

    Are you going to keep being controlled by your emotions for the rest of your life?  The answer is no.  Because today, Dr. Marc Brackett, PhD, the world’s leading expert on emotional intelligence is here to tell you,  “Success in virtually every aspect of life – career, friendship, love, and family – is determined mainly […]

  • Fearne on the loneliness of chronic pain and why she likes breaking rules

    There’s probably a bit too much pressure on reaching a definitive state of happiness isn’t there? It’s just not realistic. So Fearne’s dropping into your feed every week for some honest chat about what’s making her (and you lot) feel great, and what’s making us all feel completely rubbish.  This is a cosy little corner […]

  • Thursday Thoughts – The Importance of Movement

    On this week’s Tuesday Motivation, Lucyband I are chatting about the importance of movement. As we get older, we naturally lose both muscle and bone mass, so keeping our bodies moving is one of the best investments we can make in our long term health and wellbeing. We talk about how consistency matters more than […]

  • Invisible Abuse, Early Menopause, and the Hidden Stress Women Carry

    The Menopause Mastery Show | Invisible Abuse, Early Menopause, and the Hidden Stress Women Carry | Episode 287 with Melissa Rymer 🌿Welcome to The Menopause Mastery Show!  When Menopause Isn’t the Whole Story: The Hidden Impact of Narcissistic Abuse Many women assume hot flashes, anxiety, insomnia, brain fog, and emotional overwhelm are simply part of […]

  • 215 | 6 Simple Ways To Turn On Fat Burning After 40

    What if your body hasn’t forgotten how to burn fat—it just needs a new set of instructions? So many women reach perimenopause or menopause and suddenly feel like everything that used to work has stopped working. You may be eating less, exercising more, and trying harder than ever, yet the scale refuses to move and […]

  • PCOS to PMOS: Metabolism, Menopause, and GLP‑1s in Active Midlife Women with Carla DiGirolamo, MD, PhD (Episode 282)

    Could you have PCOS and not know it? You sure can, says reproductive endocrinologist and menopause specialist Dr. Carla DiGirolamo, who is hopeful that the recent renaming of the condition from “polycystic ovary syndrome” (PCOS) to “polyendocrine metabolic ovarian syndrome” (PMOS) will help raise awareness—and improve care. This episode breaks down what PMOS actually is, […]

  • Annette O'Toole Shares Her Secrets to Healthy Aging, Confidence & Hollywood Success: REPLAY

    Annette O’Toole, the acclaimed actress best known for playing Hope McCrea on Netflix’s hit series Virgin River and Martha Kent on Smallville, joins us for this inspiring replay conversation about her remarkable career, aging in Hollywood, marriage, motherhood, and finding lasting success in an ever-changing entertainment industry. Fans of Annette O’Toole will enjoy hearing behind-the-scenes […]

  • 93: Menopause makeover with Dr. Sanam Zahedi

    Have you looked in the mirror lately and wondered why your body suddenly feels unfamiliar — even though you're taking care of yourself the same way you always have? Menopause can bring changes that affect not only how we look, but also how we feel in our bodies and ourselves. In this episode, Dr. Jessica […]

  • Episode 226 – Heart Health After Menopause and Cancer: Don't Panic, But Don't Ignore This Either

    Heart disease is one of the biggest long-term health concerns facing cancer survivors after menopause. But before you panic, there is a lot more within your control than you might think. Just recently, I’ve seen several social media posts talking about how our risk of heart disease increases during menopause, especially if you’re not taking […]

  • Why Working Harder Stops Working After 50 (And What to Do Instead)

    This episode is sponsored by Flipping 50 Menopause Fitness Specialist. Flipping 50 Menopause Fitness Specialist.- Become a health & fitness coach who finally speaks midlife women’s language. Learn how to design workouts that balance hormones that actually get results for women in menopause. Other Episodes You Might Like: Previous Episode – What I Would Do […]

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    Why Women Gain Weight on the Same Diet as Men: Fueling, Fasting, and Biology with Dr. Stacy Sims

    In this episode of unPAUSED, Dr. Mary Claire Haver sits down with exercise physiologist and nutrition scientist Dr. Stacy Sims to unpack why so much fitness and diet advice built on male physiology leaves women confused about why the scale will not move, and why weight loss can feel so much harder for women than […]

  • Ep. 227 – Menopause Weight Loss with Sarah Kennedy

    This episode is a re-airing of a listener-favorite (and for good reason), Dr. Fiona Lovely welcomes back Sarah Kennedy, founder and CEO of Calocurb, for a candid look at why weight management during perimenopause and menopause feels like an uphill battle. The truth is, the average woman gains around 22 pounds during the menopause transition—and […]

  • Ep 536: Why Saying Yes Is Keeping Women in Menopause Stuck With Emotional Eating

    What if one of the biggest reasons you’re emotionally eating during menopause has nothing to do with food? In this episode, I share a coaching conversation that uncovered a pattern I see in so many women in menopause. The habit of saying “yes” when your body is desperately asking you to say “no.” We often […]

  • 83 – Why are women still leaving work because of their hormones?

    We’re losing experienced, talented women from the workforce because hormonal symptoms are still being overlooked, misunderstood and too often left untreated. In this episode, Dr Louise Newson is joined by Dr Mecky McNeil, a former GP and health educator who is leading work to improve understanding of hormones and menopause in workplaces across Europe. Having […]

unPAUSED with Dr. Mary Claire Haver

Welcome to unPAUSED, the podcast where bold, unfiltered conversations take place about what it really takes for women to thrive in the second half of life. Every week, Dr. Mary Claire Haver, a board-certified Obstetrician-Gynecologist, Certified Menopause Practitioner, and #1 New York Times best-selling author, tackles the conversations women actually need to hear. Dr. Haver […]

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